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Regional Distribution of Different Types of Human Papillomavirus in Cervixes of Chinese Women: A Meta-analysis

Received: 8 June 2018     Accepted: 26 June 2018     Published: 26 July 2018
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Abstract

Cervical cancer is a common gynecological malignancy that has shown a gradual increase in morbidity in recent years in China. High-risk human papillomaviruses (HR-HPVs) play a vital role in cervical cancer development and commercial vaccines are available. The overall HPV infection and geographical distribution characteristics of cervical Cancer among Chinese females have not been reported that may guide the application of the vaccines. This study systematically retrieves literature on HPV type and cervical cancer in China published from 2005 to 2017. Data are analyzed according to provinces and administrative areas for the meta-analysis. (1) SPSS17.0 software is used for the statistical data analysis. (2) χ² inspection is also employed to analyze the infection rate of different HPV types of different cervical lesion groups in seven regions of China. Results show that China’s HR-HPV16, 58, 18, 52, 33, 31, 53, 56, 59, 51, 35, and 68 infection rates are 60.49%, 11.16%, 9.68%, 7.05%, 5.61%, 3.62%, 2.88%, 2.32%, 1.96%, 1.74%, 1.53%, and 1.52%, respectively. Differences in the HR-HPV infection rate of cervical cancer were observed among different areas, especially for HPV 31, 33, 52, and 58. The genotypes of the top five HR-HPV infection rates in cervical cancer also show differences in different regions. The results offer a basis for the prevention and treatment of cervical cancer in different parts of China. HPV type distribution in relation to cervical cancer varies among different regions and parts of China. Therefore, use of available or development of new vaccines suitable for regional types is necessary to improve the efficacy of the vaccines in preventing the primary HPV infection in different areas of China.

Published in Journal of Cancer Treatment and Research (Volume 6, Issue 2)
DOI 10.11648/j.jctr.20180602.11
Page(s) 7-18
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

China, Cervical Cancer, Human Papillomavirus, Meta-analysis

References
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Cite This Article
  • APA Style

    Yue Wang, Kunpeng Zhang, Yali Hu, Hongmei Ma, Xiuyan Zheng, et al. (2018). Regional Distribution of Different Types of Human Papillomavirus in Cervixes of Chinese Women: A Meta-analysis. Journal of Cancer Treatment and Research, 6(2), 7-18. https://doi.org/10.11648/j.jctr.20180602.11

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    ACS Style

    Yue Wang; Kunpeng Zhang; Yali Hu; Hongmei Ma; Xiuyan Zheng, et al. Regional Distribution of Different Types of Human Papillomavirus in Cervixes of Chinese Women: A Meta-analysis. J. Cancer Treat. Res. 2018, 6(2), 7-18. doi: 10.11648/j.jctr.20180602.11

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    AMA Style

    Yue Wang, Kunpeng Zhang, Yali Hu, Hongmei Ma, Xiuyan Zheng, et al. Regional Distribution of Different Types of Human Papillomavirus in Cervixes of Chinese Women: A Meta-analysis. J Cancer Treat Res. 2018;6(2):7-18. doi: 10.11648/j.jctr.20180602.11

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  • @article{10.11648/j.jctr.20180602.11,
      author = {Yue Wang and Kunpeng Zhang and Yali Hu and Hongmei Ma and Xiuyan Zheng and Kelu Li and Yanjuan Xie and Lijuan Pang and Lin Tao and Jianming Hu and Yan Qi and Feng Li and Wenyi Gu and Hong Zou},
      title = {Regional Distribution of Different Types of Human Papillomavirus in Cervixes of Chinese Women: A Meta-analysis},
      journal = {Journal of Cancer Treatment and Research},
      volume = {6},
      number = {2},
      pages = {7-18},
      doi = {10.11648/j.jctr.20180602.11},
      url = {https://doi.org/10.11648/j.jctr.20180602.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20180602.11},
      abstract = {Cervical cancer is a common gynecological malignancy that has shown a gradual increase in morbidity in recent years in China. High-risk human papillomaviruses (HR-HPVs) play a vital role in cervical cancer development and commercial vaccines are available. The overall HPV infection and geographical distribution characteristics of cervical Cancer among Chinese females have not been reported that may guide the application of the vaccines. This study systematically retrieves literature on HPV type and cervical cancer in China published from 2005 to 2017. Data are analyzed according to provinces and administrative areas for the meta-analysis. (1) SPSS17.0 software is used for the statistical data analysis. (2) χ² inspection is also employed to analyze the infection rate of different HPV types of different cervical lesion groups in seven regions of China. Results show that China’s HR-HPV16, 58, 18, 52, 33, 31, 53, 56, 59, 51, 35, and 68 infection rates are 60.49%, 11.16%, 9.68%, 7.05%, 5.61%, 3.62%, 2.88%, 2.32%, 1.96%, 1.74%, 1.53%, and 1.52%, respectively. Differences in the HR-HPV infection rate of cervical cancer were observed among different areas, especially for HPV 31, 33, 52, and 58. The genotypes of the top five HR-HPV infection rates in cervical cancer also show differences in different regions. The results offer a basis for the prevention and treatment of cervical cancer in different parts of China. HPV type distribution in relation to cervical cancer varies among different regions and parts of China. Therefore, use of available or development of new vaccines suitable for regional types is necessary to improve the efficacy of the vaccines in preventing the primary HPV infection in different areas of China.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Regional Distribution of Different Types of Human Papillomavirus in Cervixes of Chinese Women: A Meta-analysis
    AU  - Yue Wang
    AU  - Kunpeng Zhang
    AU  - Yali Hu
    AU  - Hongmei Ma
    AU  - Xiuyan Zheng
    AU  - Kelu Li
    AU  - Yanjuan Xie
    AU  - Lijuan Pang
    AU  - Lin Tao
    AU  - Jianming Hu
    AU  - Yan Qi
    AU  - Feng Li
    AU  - Wenyi Gu
    AU  - Hong Zou
    Y1  - 2018/07/26
    PY  - 2018
    N1  - https://doi.org/10.11648/j.jctr.20180602.11
    DO  - 10.11648/j.jctr.20180602.11
    T2  - Journal of Cancer Treatment and Research
    JF  - Journal of Cancer Treatment and Research
    JO  - Journal of Cancer Treatment and Research
    SP  - 7
    EP  - 18
    PB  - Science Publishing Group
    SN  - 2376-7790
    UR  - https://doi.org/10.11648/j.jctr.20180602.11
    AB  - Cervical cancer is a common gynecological malignancy that has shown a gradual increase in morbidity in recent years in China. High-risk human papillomaviruses (HR-HPVs) play a vital role in cervical cancer development and commercial vaccines are available. The overall HPV infection and geographical distribution characteristics of cervical Cancer among Chinese females have not been reported that may guide the application of the vaccines. This study systematically retrieves literature on HPV type and cervical cancer in China published from 2005 to 2017. Data are analyzed according to provinces and administrative areas for the meta-analysis. (1) SPSS17.0 software is used for the statistical data analysis. (2) χ² inspection is also employed to analyze the infection rate of different HPV types of different cervical lesion groups in seven regions of China. Results show that China’s HR-HPV16, 58, 18, 52, 33, 31, 53, 56, 59, 51, 35, and 68 infection rates are 60.49%, 11.16%, 9.68%, 7.05%, 5.61%, 3.62%, 2.88%, 2.32%, 1.96%, 1.74%, 1.53%, and 1.52%, respectively. Differences in the HR-HPV infection rate of cervical cancer were observed among different areas, especially for HPV 31, 33, 52, and 58. The genotypes of the top five HR-HPV infection rates in cervical cancer also show differences in different regions. The results offer a basis for the prevention and treatment of cervical cancer in different parts of China. HPV type distribution in relation to cervical cancer varies among different regions and parts of China. Therefore, use of available or development of new vaccines suitable for regional types is necessary to improve the efficacy of the vaccines in preventing the primary HPV infection in different areas of China.
    VL  - 6
    IS  - 2
    ER  - 

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Author Information
  • Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China

  • Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China

  • Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China

  • Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China

  • Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China

  • Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China

  • Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China

  • Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China

  • Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China

  • Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China

  • Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China

  • Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

  • Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, Australia

  • Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, China

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